An alternative to the use of undifferentiated cells is that of reprogramming adult cells from nonpancreatic sources. Of these, the most promising is the liver, whose embryonic development is deeply intertwined with that of the pancreas. Several teams have now proven that the ectopic expression of master pancreatic regulators such as Pdx1 or MafA, among others, can induce the expression of pancreatic markers in liver-derived cells, both in Read the rest of this entry »